Academic Experience

2000–2004    B.S., Beijing Normal University, China

2004–2009    Ph.D., Institute of Chemistry, Chinese Academy of Sciences (with Prof. Yong-Jun Chen and Prof. Li Liu)

2009–2011    Research Scientist, Chemizon (Beijing) Ltd. & Centaurus Biopharma Co. Ltd

2011–2014    Postdoctoral Research Scientist, Columbia University, USA (with Prof. Ronald Breslow)

2015–            Professor, Institute of Chemistry, Chinese Academy of Sciences

Research Interests

Chemical Biology of Nucleic Acids

Asymmetric Synthesis of Bioactive Molecules

Selected Work

1. Biomimetic Binding and Cleavage of RNA by Synthetic Deoxypolypeptides (DOPPs)

2. Tunneling in Base-Catalyzed Isomerization of GLA to DHA under Formose Conditions

3. Discovery and Development of FAK/Pyk2 Dual Inhibitor CT-707

4. Chemo- and Enantio-selective C-H Functionalization of Indole Derivatives

Selected Publications

1. Huang, H.-Y.; Cheng, L.*; Liu, J.-J.; Wang, D.; Liu, L.*; Li, C.-J.* "Transition-Metal-Free Alkynylation of 2-Oxindoles through Radical-Radical Coupling", J. Org. Chem. 2017, 82, 2656-2663.

2. Wei, F.; Cheng, L.*; Huang, H.-Y.; Liu, J.-J.; Wang, D.; Liu, L.* "Intermolecular Dearomative Oxidative Coupling of Indoles with Ketones and Sulfonylhydrazines Catalyzed by I2 for the Synthesis of [2,3]-Fused Indoline Tetrahydropyridazines", Sci. China Chem. 2016, 59, 1311-1316.

3. Kong, D.-L.; Cheng, L.*; Yue, T.; Wu, H.-R.; Feng, W.-C.; Wang, D.; Liu, L.* "Cobalt-Catalyzed Peroxidation of 2-Oxindoles with Hydroperoxides", J. Org. Chem. 2016, 81, 5337-5344.

4. Wu, H.-R.; Cheng, L.; Kong, D.-L.; Huang, H.-Y.; Gu, C.-L.; Liu, L.*; Wang, D.; Li, C.-J.* “FeCl3-mediated radical tandem reactions of 3-benzyl-2-oxindoles with styrene derivatives for the stereoselective synthesis of spirocyclohexene oxindoles”, Org. Lett. 2016, 18, 1382–1385.

5. Li, X.-D.; Xie, L.-J.; Kong, D.-L.; Liu, L.; Cheng, L.* “Metal-free allylation of electron-rich heteroaryl boronic acids with allylic alcohols”,Tetrahedron 2016, 72, 1873-1880.

6. Kong, D.-L.; Cheng, L.; Wu, H.; Li, Y.; Wang, D.; Liu, L.* “Metal-free yne-addition/1,4-aryl migration/decarboxylation cascade reaction of alkynoates with Csp3-H centers”, Org. Biomol. Chem. 2016, 14, 2210−2217.

7. Cheng, L.; Charles, D.*; Breslow, R.* “Evidence for tunneling in base-catalyzed isomerization of glyceraldehyde to dihydroxyacetone by hydride shift under formose conditions”, Proc. Natl. Acad. Sci. USA 2015, 112, 4218−4220.

8. Cheng, L.; Mahendran, A.; Gonzalez, R. L. Jr.*; Breslow, R.* “Deoxypolypeptides bind and cleave RNA”, Proc. Natl. Acad. Sci. USA 2014,111, 7920–7924.

9. Cheng, L.; Abhilash, K. G.; Breslow, R.* “Binding and biomimetic cleavage of the RNA poly(U) by synthetic polyimidazoles”, Proc. Natl. Acad. Sci. USA 2012, 109, 12884−12887.

10. Cheng, L.; Liu, L.*; Li, C.; Jia, H.; Wang, D.; Chen, Y. J.* “Nucleophilic addition of regioselectively lithiated indoline with aldimines for the syntheses of 2- and 7-indolinyl methanamine derivatives”, Tetrahedron Lett. 2012, 53, 4004−4007.

11. Zhang, T.; Cheng, L.; Hameed, S.; Liu, L.*; Wang, D.; Chen, Y. J.* “Highly enantioselective Michael addition of 2-oxindoles to vinyl selenone in RTILs catalyzed by a Cinchona alkaloid-based thiourea”, Chem. Commun. 2011, 47, 6644−6646.

12. Zhang, T.; Cheng, L.; Liu, L.*; Wang, D.; Chen, Y. J.* “Asymmetric organocatalytic N-nitroso-aldol reaction of oxindoles”, Tetrahedron: Asymmetry 2010, 21, 2800−2806.

13. Cheng, L.; Liu, L.*; Wang, D.; Chen, Y. J.* “Highly enantioselective and organocatalytic alpha-amination of 2-oxindoles”, Org. Lett. 2009,11, 3874−3877.

14. Cheng, L.; Liu, L.*; Jia, H.; Wang, D.; Chen, Y. J.* “Enantioselective organocatalytic anti-Mannich-type reaction of N-unprotected 3-substituted 2-oxindoles with aromatic N-Ts-aldimines”, J. Org. Chem. 2009, 74, 4650−4653.

15. Cheng, L.; Liu, L.*; Sui, Y.; Wang, D.; Chen, Y. J.* “Highly diastereoselective reactions of 2-lithiated indoles with chiral N-tert-butanesulfinyl aldimines for the synthesis of chiral (2-indolyl) methanamine derivatives”, Tetrahedron: Asymmetry 2007, 18, 1833−1843.

16.校登明，程靓，刘希杰，胡远东，许新合，刘志华，张立鹏，吴伟，王树龙，沈宇，李根，王银，赵胜，李舂龙，唐佳，于洪灏，“作为FAK/Pyk2抑制剂的2,4-二氨基-6,7-二氢-5H-吡咯并[2,3]嘧啶衍生物”，中国专利，授权号：ZL 201110002776.3，公告日：2015年1月28日。

17. Xiao, D. M.; Cheng, L.; Liu, X. J.; Hu, Y. D.; Xu, X. H.; Liu, Z. H.; Zhang, L. P.; Wu, W.; Wang, S. L.; Shen, Y.; Li, G.; Wang, Y.; Zhao, S.; Li, C. L.; Tang, J.; Yu, H. H. “2,4-Diamino-6,7-dihydro-5H-pyrrolo[2,3]pyrimidine derivatives as FAK/Pyk2 inhibitors”, US Patent 9428508 B2, Date of Patent: 08/30/2016.

18.校登明，程靓，刘希杰，胡远东，许新合，刘志华，张立鹏，吴伟，王树龙，沈宇，李根，王银，赵胜，李舂龙，唐佳，于洪灏，“作为FAK/Pyk2抑制剂的2,4-二氨基-6,7-二氢-5H-吡咯并[2,3]嘧啶衍生物”，中国专利，申请号：201280004821.1，申请日：2012年1月7日。