Speaker: Xia Fei

Time: Friday, June 23, 2017, 16:00 p.m.

Location: 5#100 Conference Room

Jiadifenolide is an architecturally complex seco-prezizaane-type sesquiterpenoid isolated from the pericarps of Illicium jiadifengpi. It features a highly oxygenated cage-like architecture with seven contiguous stereocenters. The biological activity studies show that Jiadifenolide displays potent neurotrophic activity at very low concentration and is regarded as a promising lead compound for developing drugs for neurodegenerative diseases. The combination of a challenging cage-like motif and intriguing biological properties has promoted the development of efficient strategies toward their chemical syntheses. This report focuses on the recent advances in the total synthesis of Jiadifenolide.

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CURRICULUM VITAE

Educational background

2004.9-2008.6      Dezhou University, B.S.

2008.9-2011.4      East China University of Science and Technology, M.S.

2011.5-2016.8      ICCAS

2016.9-present     IC CAS, Ph.D candidate (with Prof. Song Ye)