Academic Experience

1989-1995   M.Sc. and Ph.D. Institute of Chemistry, Chinese Academy of Sciences

1995-1996   Assistant Professor, Institute of Chemistry, Chinese Academy of Sciences

1996-1999   Postdoctoral Research Fellow, University of Sunderland, UK

1999-2001   Senior Research Fellow, University of Oxford, UK

2001-           Professor, Institute of Chemistry, Chinese Academy of Sciences

Research Interests

Synthesis and biological activities of natural products

Carbohydrate chemistry and biology

Synthetic technique of important active pharmaceutical ingredients (APIs) and key intermediates

Selected Work

1. Synthesis and biological activities of polyhydroxylated alkaloids

2. Total synthesis and biological activities of broussonetine I and J₂

3. Total synthesis and biological activities of pochonicine and its analogs

4. Synthesis and biological activities of australine and its fluorinated derivatives

5. Concise synthesis of calystegines B₂ and B₃ via intramolecular NHK reaction

Selected Publications

1. Li, Y. X.; Iwaki, R.; Kato, A.*; Jia, Y. M.; Fleet, G. W. J.; Zhao, X.; Xiao, M.; Yu, C. Y.*, “Fluorinated Radicamine A and B: Synthesis and Glycosidase Inhibition”Eur. J. Org. Chem. 2016, (7), 1429-1438.

2. Li, Y. X.; Kinami, K.; Hirokami, Y.; Kato, A.*; Su, J. K.; Jia, Y. M.; Fleet, G. W. J.; Yu, C. Y.*“Gem-difluoromethylated and trifluoromethylated derivatives of DMDP-related iminosugars: synthesis and glycosidase inhibition” Org. Biomol. Chem. 2016, 14 (7), 2249-2263.

3. Qian, B. C.; Kamori, A.; Kinami, K.; Kato, A.*; Li, Y. X.; Fleet, G. W. J.; Yu, C. Y.* “Epimerization of C5 of an N-hydroxypyrrolidine in the synthesis of swainsonine related iminosugars” Org. Biomol. Chem. 2016, 14 (19), 4488-4498.

4. Song, Y. Y.; Kinami, K.; Kato, A.*; Jia, Y. M.; Li, Y. X.; Fleet, G. W. J.; Yu, C. Y.* “First total synthesis of (+)-broussonetine W: glycosidase inhibition of natural product & analogs” Org. Biomol. Chem. 2016, 14 (22), 5157-5174.

5. Wang, H. Y.; Kato, A.*; Kinami, K.; Li, Y. X.; Fleet, G. W. J.; Yu, C. Y.* “Concise synthesis of calystegines B-2 and B-3 via intramolecular Nozaki-Hiyama-Kishi reaction” Org. Biomol. Chem. 2016, 14 (21), 4885-4896.

6. Li, Y.-X.; Shimada, Y.; Sato, K.; Kato, A.*; Zhang, W.; Jia, Y.-M.; Fleet, G. W. J.; Xiao, M.; Yu, C.-Y.*, “Synthesis and Glycosidase Inhibition of Australine and Its Fluorinated Derivatives” Org. Lett. 2015, 17 (3), 716-719.

7. Li, Y.-X.; Shimada, Y.; Adachi, I.; Kato, A.*; Jia, Y.-M.; Fleet, G. W. J.; Xiao, M.; Yu, C.-Y*., “Fluorinated and Conformationally Fixed Derivatives of L-HomoDMDP: Synthesis and Glycosidase Inhibition.” J. Org. Chem. 2015, 80 (10), 5151-5158.

8. Zhu, J.-S.; Nakagawa, S.; Chen, W.; Adachi, I.; Jia, Y.-M.; Hu, X.-G.; Fleet, G. W. J.; Wilson, F. X.; Nitoda, T.; Horne, G.; van Well, R.; Kato, A.*; Yu, C.-Y.*, “Synthesis of Eight Stereoisomers of Pochonicine: Nanomolar Inhibition of β-N-Acetylhexosaminidases.” J. Org. Chem. 2013, 78, 10298-10309.

9. Zhao, H.; Kato, A.; Sato, K.; Jia, Y. M.; Yu, C. Y., “Total Synthesis and Glycosidase Inhibition of Broussonetine I and J₂.” J. Org. Chem. 2013,78 (16), 7896-7902

10. Zhao, W.-B.; Nakagawa, S.; Kato, A.; Adachi, I.; Jia, Y.-M.; Hu, X.-G.; Fleet, G. W. J.; Wilson, F. X.; Horne, G.; Yoshihara, A.; Izumori, K.; Yu, C.-Y.* “ General Synthesis of Sugar-Derived Azepane Nitrones: Precursors of Azepane Iminosugars” J. Org. Chem. 2013 78, 3208-3221.

11. Zhang, Z.-L.; Nakagawa, S.; Kato, A.; Jia, Y.-M.; Hu, X.-G.; Yu, C.-Y.* “A concise stereoselective synthesis of (-)-erycibelline” Org. Biomol. Chem. 2011, 7713-7719.( hot paper)

12. Zhang, W.; Sato, K.; Kato, A.; Jia, Y.-M.; Hu, X.-G.; Wilson, F. X.; van Well, R.; Horne, G.; Fleet, G. W. J.; Nash, R. J.; Yu, C.-Y.* “Synthesis of fully substituted polyhydroxylated pyrrolizidines via Cope-House cyclization” Org. Lett. 2011, 13, 4414-4417.

13. Li, Y. X.; Huang, M. H.; Yamashita, Y.; Kato, A.; Jia, Y. M.; Wang, W. B.; Fleet, G. W. J.; Nash, R. J.; Yu, C. Y.* “L-DMDP, L-homoDMDP and their C-3 fluorinated derivatives: Synthesis and glycosidase-inhibition” Org. Biomol. Chem. 2011, 9, 3405-3414.

14. Hu, X.-G.; Bartholomew, B.; Nash, R. J.; Wilson, F. X.; Fleet, G. W. J.; Nakagawa, S.; Kato, A.; Jia, Y.-M.; Well, R. V.; Yu, C.-Y.* “Synthesis and glycosidase inhibition of the enantiomer of (-)-steviamine, the first example of a new class of indolizidine alkaloid” Org. Lett. 2010, 12, 2562-2565.

15. Wang, W.-B.; Huang, M.-H.; Li, Y.-X.; Rui, P.-X.; Hu, X.-G.; Zhang, W.; Su, J.-K.; Zhang, Z.-L.; Zhu, J.-S.; Xu, W.-H.; Xie, X.-Q; Jia Y.-M.;* Yu, C. Y.* “A practical synthesis of sugar-derived cyclic nitrones: Powerful synthons for the synthesis of iminosugars” Synlett 2010, 488-492.