Academic Experience

1991.9-1995.6           B.S., East China Normal University

1997.9-2002.7           Ph.D., Shanghai Institute of Organic Chemisitry, CAS (Supervisor: Prof. Li-Xin Dai & Prof. Yong Tang)

2002.9-2005.7           Postdoc., Visiting Scholar, National Institutes of Health, USA (with Prof. Kenneth L. Kirk)

2005.7-                      Professor, ICCAS

Honors and Awards

2002  Special Prize of the Present Scholarship

2004  National Top 100 Ph.D. Thesis

2012  Thieme Chemistry Journals Award

2012  The 2^nd Class Prize of National Natural Science Award of China (Third awardee)

2014  National Science Fund for Distinguished Young Scholar

Research Interests

N-heterocyclic carbene catalysis

Photocatalysis, Cooperative catalysis

Domino reactions

Heterocycles synthesis

Selected Work

1. N-Heterocyclic carbene (NHC) catalyzed cross-coupling of homoenolate and enolate

2. NHC-catalyzed [3+4] annualtions

3. NHC-catalyzed Synthesis of multisubstituted benzenes

Selected Publications

1. Chen, X.-Y.; Chen, K.-Q.; Sun, D.-Q.;* Ye, S.* N-Heterocyclic carbene-catalyzed oxidative [3 + 2] annulation of dioxindoles and enals: cross coupling of homoenolate and enolate Chem. Sci., 2017, 8, 1936.

2. Zhang, Z.-F.; Chen, K.-Q.; Zhang, C.-L.; Ye, S.* N-heterocyclic carbene-catalyzed synthesis of spirocyclopentene-oxindoles from bromoenalsChem. Commun., 2017, 53, 4327.

3. Yi, L.; Zhang, Y.; Zhang, Z.-F.; Sun, D.-Q.;* Ye, S.* Synthesis of Dihydropyridinone-Fused Indoles and α‑Carbolines via N‑Heterocyclic Carbene-Catalyzed [3+3] Annulation of Indolin-2-imines and Bromoenals Org. Lett. 2017, 19, 2286.

4. Zhang, C.-L.; Gao, Z.-H.; Liang, Z.-Q.; Ye, S.* N-Heterocyclic Carbene-Catalyzed Synthesis of Multi-Substituted Benzenes from Enals and α-Cyano-β-methylenones Adv. Synth. Catal. 2016, 358, 2862.

5. Zhang, C.-L.; Ye, S.* N‑Heterocyclic Carbene-Catalyzed Construction of 1,3,5-Trisubstituted Benzenes from Bromoenals and α‑Cyano-β-methylenones Org. Lett. 2016, 18, 6408.

6. Liang, Z.-Q.; Gao, Z.-H.; Jia W.-Q.; Ye, S.* “Bifunctional N-Heterocyclic Carbene Catalyzed [3+4] Annulation of Enals and Aurones” Chem. Eur. J. 2015, 21, 1868.

7. Chen, X.-Y.; Gao, Z.-H.; Song, C.-Y.; Zhang, C.-L. Wang, Z.-X.;* Ye, S.* “N-Heterocyclic Carbene Catalyzed Cyclocondensation of α,β-Unsaturated Carboxylic Acids: Enantioselective Synthesis of Pyrrolidinone and Dihydropyridinone Derivatives” Angew. Chem. Int. Ed. 2014, 53, 11611.

8. Chen, X.-Y.; Xia, F.; Cheng, J.-T.; Ye, S.* “Highly Enantioselective γ-Amination by N-Heterocyclic Carbene Catalyzed [4+2] Annulation of Oxidized Enals and Azodicarboxylates” Angew. Chem. Int. Ed. 2013, 52, 10644.

9. Lv, H.; Jia, W.-Q.; Sun, L.-H.; Ye, S.* “N-Heterocyclic carbene catalyzed [4+3] annulation of enals and o-quinone methides: highly enantioselective synthesis of benzo-ɛ-lactones A” Angew. Chem. Int. Ed. 2013, 52, 8607.

10. Shen, L.-T.; Jia, W.-Q.; Ye, S.* “Catalytic [4+2] Cyclization of α,β-Unsaturated Acyl Chlorides with 3-Alkylenyloxindoles: Highly Diastereo- and Enantioselective Synthesis of Spirocarbocyclic Oxindoles” Angew. Chem. Int. Ed. 2013, 52, 585.

11. Shen, L.-T.; Sun, L.-H.; Ye, S.* “Highly enantioselective γ-amination of α,β-unsaturated acyl chlorides with azodicarboxylates: Efficient synthesis of chiral γ-amino acid derivatives” J. Am. Chem. Soc. 2011, 133, 15894.

12. Shao, P.-L.; Chen, X.-Y.; Ye, S.* “Formal [3+2] cycloaddition of ketenes and oxaziridines catalyzed by chiral Lewis bases: Enantioselective synthesis of oxazolin-4-ones” Angew. Chem. Int. Ed. 2010, 49, 8412.

13. Huang, X.-L.; He, L.; Shao, P.-L.; Ye, S.* “[4+2] Cycloaddition of ketenes with N-benzoyldiazenes catalyzed by N-heterocyclic carbenes”Angew. Chem. Int. Ed. 2009, 48, 192.

14. Zhang, Y.-R.; He, L.; Wu, X.; Shao, P.-L.; Ye, S.* “Chiral N-heterocyclic carbene catalyzed staudinger reaction of ketenes with imines: Highly enantioselective synthesis of N-Boc β-Lactams” Org. Lett. 2008, 10, 277.