Academic Experience

1985.9-1989.7          B.S., Xiangtan University

1989.9-1992.7          M.S., Institute of Chemistry, Chinese Academy of Sciences (ICCAS)

1995.2-1998.2          Ph.D., The Hong Kong Polytechnic University

1992.8-1998.4          Research Assistant and Assistant Professor, ICCAS

1998.4-2003.4          Associate Professor and Principal Investigator, ICCAS

2003.4-                     Professor, ICCAS

Honors and Awards

2003, National Science Fund for Distinguished Young Scholar

2005, The 2nd Class Awards for National Natural Science (rank 2)

2012, Asian Core Program Lectureship Award

2013, National Hundred, Thousand and Ten Thousand Talent Project

Research Interests

Asymmetric catalysis

Environmentally benign catalytic reactions

Synthesis of biologically active heterocyclic compounds

Molecular design and self-assembly of functional dendrimers

Selected Work

1. Asymmetric hydrogenation of heteroaromatic compounds and imines

2. Asymmetric hydrogenation in the core of dendrimers

3. Versatile dendritic organogelators and their applications

Selected Publications

1. Miao,T.; Tian, Z.-Y.;  He, Y.-M.; Chen, F.; Chen, Y.; Yu, Z.-X.*; Fan, Q.-H.* “Asymmetric hydrogenation of in situ generated isochromenylium intermediates by copper/ruthenium tandem catalysis” Angew. Chem. Int. Ed. 2017, 56, 4135–4139.

2. Yang, Z.; Chen, F.*; He, Y.-M.; Yang, N.; Fan, Q.-H.* “Highly enantioselective synthesis of indolines: Asymmetric hydrogenation at ambient temperature and pressure with cationic ruthenium diamine catalysts” Angew. Chem. Int. Ed. 2016, 55, 13863–13866.

3. Ma, W.; Zhang, J.; Xu, C.; Chen, F.; He, Y.-M.; Fan, Q.-H.* “Highly enantioselective direct synthesis of endocyclic vicinal diamines by chiral Ru(diamine)-catalyzed hydrogenation of 2,2’-bisquinoline derivatives”, Angew. Chem. Int. Ed. 2016, 55, 12891–12894.

4. Zhang, J.; Chen, F.; He, Y.-M.; Fan, Q.-H.* “Asymmetric ruthenium-catalyzed hydrogenation of 2,6-disubstituted 1,5-naphthyridines: Access to chiral 1,5-diaza-cis-decalins” Angew. Chem. Int. Ed. 2015, 54, 4622–4625.

5. Ouyang, G.-H.; He, Y.-M.; Li, Y.; Xiang, J.; Fan, Q.-H.* “Cation-triggered switchable asymmetric catalysis with chiral aza-CrownPhos”Angew. Chem. Int. Ed. 2015, 54, 4334–4337.

6. Chen, F.; Ding, Z.-Y.; He, Y.-M.; Fan, Q.-H.* “Synthesis of optically active 1,2,3,4-tetrahydroquinolines via asymmetric hydrogenation using iridium-diamine catalyst”, Org. Synth. 2015, 92, 213–226.

7. He, Y.-M.; Feng, Y.; Fan, Q.-H.* “Asymmetric hydrogenation in the core of dendrimers” Acc. Chem. Res. 2014, 47, 2894−2906.

8. Zhao, Z.; Chen, C.; Dong, Y.; Yang, Z.; Fan, Q.-H.*; Liu, D.* “Thermally triggered frame-guided assembly” Angew. Chem. Int. Ed. 2014, 53, 13468–13470.

9. Wang, T.; Chen, F.; Qin, J.; He, Y.-M.; Fan, Q.-H.* “Asymmetric ruthenium-catalyzed hydrogenation of 2- and 2,9-substituted 1,10-phenanthrolines” Angew. Chem. Int. Ed. 2013, 51, 7172–7176.

10. Ding, Z.; Chen, F.; Qin, J.; He, Y.-M.; Fan, Q.-H.* “Asymmetric hydrogenation of 2,4-disubstituted 1,5-benzodiazepines using cationic ruthenium diamine catalysts: An unusual achiral counteranion induced reversal of enantioselectivity” Angew. Chem. Int. Ed. 2012, 51, 5706–5710.

11. Wang, T.; Zhuo, L.; Li, Z.; Chen, F.; Ding, Z.; He, Y.-M.; Fan, Q.-H.*; Xiang, J.; Yu, Z.-X.*; Chan, A. S. C. “Highly enantioselective hydrogenation of quinolines using phosphine-free chiral cationic ruthenium catalysts: Scope, mechanism, and origin of enantioselectivity” J. Am. Chem. Soc. 2011, 133, 9878–9891.

12. Chen, Q.; Feng, Y.; Zhang, D.*; Zhang, G.; Fan, Q.-H.*; Sun, S.; Zhu, D. “Light-triggered self-assembly of a spiropyran-functionalized dendron into nano-/micrometer-sized particles and photoresponsive organogel with switchable fluorescence” Adv. Funct. Mater. 2010, 20, 36–42.

13. Feng, Y.; Liu, Z.; Liu, J.; He, Y.-M.*; Zheng, Q.; Fan, Q.-H.* “Peripherally dimethyl isophthalate- functionalized poly(benzyl ether) dendrons: A new kind of unprecedented highly efficient organogelators” J. Am. Chem. Soc. 2009, 131, 7950–7951.

14. Tang, W.; Xu, L.*; Fan, Q.-H.*; Wang, J.; Fan, B.; Zhou, Z.; Lam, K.-H.; Chan, A. S. C.* “Asymmetric hydrogenation of quinoxalines with diphosphinite ligands: A practical synthesis of enantioenriched substituted tetrahydroquinoxalines” Angew. Chem. Int. Ed. 2009, 48, 9135–9238.

15. Zhou, H.; Li, Z.; Wang, Z.; Wang, T.; Xu, L.; He, Y.-M.; Fan, Q.-H.*; Pan, J.; Gu, L.; Chan, A. S. C.* “Hydrogenation of quinolines using a recyclable phosphine-free chiral cationic ruthenium catalyst: Enhancement of catalyst stability and selectivity in an ionic liquid ” Angew. Chem. Int. Ed. 2008, 47, 8464–8467.

16. Wang, Z.; Deng, G.-J.; Li, Y.; He, Y.-M.; Tang, W.-J.; Fan, Q.-H.* “Enantioselective hydrogenation of quinolines catalyzed by Ir(BINAP)-cored dendrimers: Dramatic enhancement of catalytic activity” Org. Lett. 2007, 9, 1243–1246.

17. Fan, Q.-H.; Li, Y.-M.*; Chen, A. S. C.* “Recoverable catalysts for asymmetric organic synthesis” Chem. Rev. 2002, 102, 3385–3466.

18. 丁奎岭，范青华 主编，《不对称催化新概念与新方法》，化学工业出版社，2008年 (Asymmetric Catalysis: New Concepts and Methods, Editors: Kuiling Ding and Qing-Hua Fan, China Chemical Industry Press, 2008).