FeCl3?Mediated Radical Tandem Reactions of 3?Benzyl-2-oxindoles with Styrene Derivatives for the Stereoselective Synthesis of Spirocyclohexene Oxindoles
Hong-Ru Wu, Liang Cheng, De-Long Kong, Hong-Yan Huang, Chun-Ling Gu, Li Liu,*, Dong Wang, and Chao-Jun Li*
A novel FeCl3-mediated reaction of 3-benzyl-2-oxindoles with styrene derivatives was developed. The reaction provided spirocyclohexene oxindoles in good yields and excellent diastereoselectivities via a tandem radical addition cyclization process.
This work has been published in Org. Lett. 2016, 18, 1382-1385.