Xiao-Yang Jin, Li-Jun Xie, Hou-Ping Cheng, An-Di Liu, Xue-Dong Li, Dong Wang, Liang Cheng*, and Li Liu*

We disclose herein a Ru(II)-catalyzed decarboxylative and oxidative coupling of N-substituted indolyl carboxylic acids with broad substrate scope in an aqueous solution. This method provides a sustainable and efficient access to synthesize various indole-fused cyclohexanyl acetic acids under mild conditions.

This work has been published in J. Org. Chem. 2018, 83, 7514.