N-Heterocyclic Carbene-Catalyzed Annulation of alpha-Chloroaldehydes with gamma-/delta-Amino-alpha,beta-Unsaturated Ketones: Enantioselective Synthesis of Pyrrolidones and Piperidones.
Zhang, Z. F.; Zhang, C. L.; Song, Z. Y.; Gao, Z. H.; Ye, S.*
Pyrrolidones and Piperidones: The N-heterocyclic carbene-catalyzed [2+3] and [2+4] annulations of a-chloroaldehdydes with - or -amino-α,β-unsaturated ketones were developed to give 3,4-disubstituted pyrrolidones and piperidones in good yields with exclusive trans-selectivities and excellent enantioselectivities.
This work has been published in Chem. Eur. J. 2018, 24, 8302.